报告人：Prof. Min Zhuo （卓敏） 
    CND, FIST, XJTU /University of Toronto, Canada

讲座题目：Neurobiological investigations of pain and emotion

地点：科学馆101，兴庆校区

时间：2016年4月18日（星期一），上午10:00

简介：卓敏教授是神经生物学领域的国际知名专家。他是第一份Online国际性痛觉研究杂志Molecular Pain主编和Molecular Brain的Founding主编。他主编了第一本分子痛的英文教科书由国家高等教育出版社和Springer联合出版。他在国际权威杂志如Nature，Science，Neuron，Nature Neurosci，J Neurosci等杂志上发表研究论文200余篇, 综述24篇. 论文被引用近17409次，H-index为72（2016年04月14日数据）。除了致力于基础研究，他认为生物医学研究最终应该造福于人类。他己拥有5项有关新药研制的国际及美国专利。

摘要：Neurons in the anterior cingulate cortex (ACC) play important roles in pain perception and emotion. Recent neurobiological studies suggest that synaptic plasticity taking place in sensory pathways, from spinal dorsal horn to cortical areas including the ACC. At the synaptic level, potentiation of excitatory transmission caused by injuries may be mediated by the enhancement of glutamate release from presynaptic terminals and potentiated postsynaptic responses of AMPA receptors.  However, little is known possible functional implications of pre- vs post-synaptic changes in the ACC. Here we characterized two forms of long-term potentiation (LTP) in the anterior cingulate cortex (ACC); a presynaptic form (pre-LTP) that requires kainate receptors and a postsynaptic form (post-LTP) that requires N-methyl-D-aspartate receptors. Pre-LTP also involves adenylyl cyclase and protein kinase A and is expressed via a mechanism involving hyperpolarization-activated cyclic nucleotide-gated (HCN) channels. Interestingly, chronic pain and anxiety both result in selective occlusion of pre-LTP. Significantly, microinjection of the HCN blocker ZD7288 into the ACC in vivo produces both anxiolytic and analgesic effects. Our results provide a mechanism by which two forms of LTP in the ACC may converge to mediate
the interaction between anxiety and chronic pain.   

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